LITERATURE STUDY OF THE CONTENT OF SECONDARY METABOLITES OF EAST BORNEO LEDANG PLANTS (ARTOCARPUS LANCEIFOLIUS) AS ANTICITOTOXIC
STUDI LITERATUR KANDUNGAN SENYAWA METABOLIT SEKUNDER TANAMAN KELEDANG (ARTOCARPUS LANCEIFOLIUS) EAST BORNEO SEBAGAI ANTISITOTOKSIK
DOI:
https://doi.org/10.54902/ktdqah74Keywords:
Anticytotoxic, Artocarpus lanceifolius, Cancer, Secondary metabolites, Keledang plant.Abstract
Cancer is characterized by the presence of abnormal cells that can grow uncontrollably and have the ability to invade organs, migrate to other tissues, and spread to distant sites. In Indonesia, cervical cancer is the second most common cancer after breast cancer, and it increases annually. The prevalence of cancer, according to a doctor's diagnosis, is 2.06 per thousand cases in urban areas and 1.47 per thousand in rural areas (Riskesdas, 2018). The keledang plant (Artocarpus lanceifolius), a typical fruit of Kalimantan, contains phenolic compounds and flavonoids, which are used as medicinal ingredients due to their cytotoxic properties. Several prenylated flavonoid compounds, including 23 types of artoindonesianin, have been successfully isolated (Bailly, 2021). The purpose of this literature study was to review the secondary metabolite compounds and the bioactivity of the keledang plant in inhibiting cancer cell growth. The method used in searching for review articles in national and international journals has been indexed by Scopus and accredited by SINTA using the PubMed, Google Scholar, and Research Gate platforms. A Systematic Literature Review (SLR) is an evidence-based review in identifying, assessing, and interpreting all research results. focused on a single research urgency. Research results showed that the keledang plant produces various isoprenylated flavonoid compounds containing an isoprenyl side chain at C-3, with a 2,4-dioxygenated or 2,4,5-trioxygenated pattern in the B ring of the 2,3-flavone skeleton, showing significant cytotoxic effects against murine leukemia P-388 cells (Musthapa, 2009). Artoindonesianin P and W, isolated from Artocarpus lanceifolius, were found to inhibit human neutrophil elastase (IC50 = 28.7 and 11.2 μM, respectively) (Ban et al., 2020). Artobiloxanthone actively binds the enzyme transglutaminase 2 (TG2), an enzyme that is an anticancer target (Akram, 2018).
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