LITERATURE STUDY OF THE CONTENT OF SECONDARY METABOLITES OF EAST BORNEO LEDANG PLANTS (ARTOCARPUS LANCEIFOLIUS) AS ANTICITOTOXIC
STUDI LITERATUR KANDUNGAN SENYAWA METABOLIT SEKUNDER TANAMAN KELEDANG (ARTOCARPUS LANCEIFOLIUS) EAST BORNEO SEBAGAI ANTISITOTOKSIK
DOI:
https://doi.org/10.54902/ktdqah74Kata Kunci:
Anticytotoxic, Artocarpus lanceifolius, Artelastin, Cancer, Secondary metabolite, Keledang plantAbstrak
The prevalence of cancer based on doctor's diagnosis is 2.06 per thousand cases in urban areas and 1.47 per thousand in rural areas (Riskesdas, 2018). In Indonesia, cervical cancer ranks second after breast cancer and continues to increase every year. The keledang plant (Artocarpus lanceifolius), a fruit native to Kalimantan, empirically contains phenolic secondary metabolites, especially flavonoids, which are used as medicinal ingredients due to their cytotoxic properties. Several prenylated flavonoid compounds contained in 23 types of artoindonesianin groups have been successfully isolated from keledang bark and wood (Bailly, 2021). The purpose of this literature study is to review the content of secondary metabolites and the bioactivity of the keledang plant in inhibiting cancer cell growth. Using the Systematic Literature Review (SLR) method, articles both national and international that are indexed in Scopus and accredited by SINTA were reviewed using the PubMed, Google Scholar, and Researchgate platforms. The inclusion and exclusion criteria were based on the secondary metabolite compounds contained in the keledang plant (Artocarpus lanceifolius). The results of the study showed that the keledang plant (Artocarpus lanceifolius) contains prenylated flavonoid secondary metabolites that have anticytoxic activity through TG2 inhibition and apoptosis induction. However, the data is still very limited in terms of molecular data and preclinical testing because it is only based on empirical testing, so further research is needed to prove its anticytoxic activity.
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Referensi
Akram Taleghani dan Zahra Tayarani-Najaran. (2018). Flavonoid Alami Sitotoksik yang Ampuh: Jurnal Batas Perspektif. Departemen Kimia, Fakultas Sains, Universitas Gonbad Kavous, PO Box 163, Iran.
Bailly, C. (2021). Anticancer mechanism of artonin E and related prenylated flavonoids from the medicinal plant Artocarpus elasticus. Asian Journal of Natural Product Biochemistry, 19(2).
Ban YJ, Baiseitova A, Nafiah MA, Kim JY, Park KH. 2020. Manusia dihydrobenzoxanthones penghambat neutrofil elastase dan flavon teralkilasi dari Artokarpus elastiskulit akar. Jurnal Aplikasi Biol Kimia 63: 63.
Hamsidar, H., Soekamto, N., M Syah, Y., & Firdaus, F. (2019). Determination of Secondary Metabolites, Toxicity and Antioxidant Activities of Bark Extracts of Artocarpus Lanceifolius Roxb. International research journal of pharmacy.
Haskas, Y., Permadani, T. Y. N., & Restika, I. (2021). Literature Review: Tanaman obat dengan multiple Effect Pada Penderita Diabetes Mellitus. (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat), 6(1).
Hidayah, N., Daniel, D., & Marliana, E. (2021). Aktivitas Ekstrak Metanol Daun Keledang (artocarpus lanceifolius roxb) Sebagai Antiinflamasi. IN PROSIDING SEMINAR KIMIA (pp. 126-131).
Kanthe, P. S., Patil, B. S., Das, K. K., & Parvatikar, P. P. (2021). Structural analysis and prediction of potent bioactive molecule for eNOS protein through molecular docking. In Silico Pharmacology, 9(1), 1-10.
Losuwannarak N, Sritularak B, Chanvorachote P. 2018. Cycloartobioxanthone Menginduksi Apoptosis Sel Kanker Paru Manusia melalui Jalur Apoptosis yang bergantung pada Mitokondria. Di Vivo 32: 71-78.
Isyahro, N. R., Widodo, N. T., & Marliana, E. (2021). Potensi Aktivitas Antioksidan Ekstrak Metanol Daun Keledang (Artocarpus lanceifolius Roxb). In PROSIDING SEMINAR NASIONAL KIMIA (pp. 121-125).
Minakawa T, Toume K, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M. 2013. Prenilflavonoid diisolasi dariArtocarpus champedendengan aktivitas mengatasi resistensi TRAIL. Fitokimia 96: 299-304. Corrigendum dalam Fitokimia 2014, 106:207.
Musthapa I, Hakim EH, Juliawaty LD, Syah YM, Achmad SA. 2010. Flavon terprenilasi dari sebagian orang IndonesiaArtokarpusdan sifat antimalarianya. Pabrik Obat 2: 157-160
Naspiah, N., & Pratama, M. R. F. (2021). Xanthine Oxidase Inhibition Activity and ADMET Properties of Terap (Artocarpus odoratissimus Blanco) Leaves Metabolites: Phytochemical Screening and In Silico Studies. Pharmacognosy Journal, 13(5).
Nimnuan-ngam S, Yangnok K, Innajak S, Watanapokasin R. 2020. Efek artonin E pada induksi kematian sel apoptosis pada sel kanker usus besar. Jurnal Biomarker Epidemiol Kanker Sebelumnya 29, B061.
Parvatikar PP, Madagi SB. 2021. Analisis Docking Molekuler: Interaksi Studi Senyawa Alami dengan Protein TG2 Manusia. Dalam S-1.
Plaibua K, Pongrakhananon V, Chunhacha P, Sritularak B, Chanvorachote P. 2013. Pengaruh artonin E terhadap kemampuan migrasi dan invasi sel kanker paru-paru manusia. Jurnal Antikanker Res 33: 3079-3088.
Pratiwi, R., & Nurlaeni, Y. (2020). Screening of plant collection of Cibodas Botanic Gardens, Indonesia with anticancer properties. Biodiversitas Journal of Biological Diversity, 21(11).
Rahman MA, Ramli F, Karimian H, Dehghan F, Nordin N, Ali HM, Mohan S, Hashim NM. 2016. Artonin E Menginduksi Apoptosis melalui Disregulasi Mitokondria pada Sel Kanker Ovarium SKOV-3. Journal PLoS Satu 11: e0151466.
Riskesdas, K. (2018). Hasil Utama Riset Kesehata Dasar (RISKESDAS). Journal of Physics A: Mathematical and Theoretical, 44 (8), 1–200. https://doi.org/10.1088/1751-8113/44/8/085201.
Rivana, EJ (2020). Keanekaragaman Senyawa Flavonoid Yang Tercetak Dari Tanaman Pisang (Artocarpus lanceifolius roxb) dan Aktivitas Sitoksiknya Terhadap Sel Murine Leukemia P-388 (Disertasi Doktor, Universitas Pendidikan Indonesia).
Santos, C. M., & Silva, A. (2020). The antioxidant activity of prenylflavonoids. Molecules, 25(3), 696.
Seca, A. M., & Pinto, D. C. (2018). Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application. International journal of molecular sciences, 19(1), 263.
Setiawan, H., Khaerunnisa, R. N., Ariyanto, H., Fitriani, A., Firdaus, F. A., & Nugraha, D. (2021). Yoga Meningkatkan Kualitas Hidup Pada Pasien Kanker: Literature Review. Journal of Holistic Nursing Science, 8(1), 75-88.
Soekamto, N. H., & Syah, Y. M. (2019). Prenylated flavon and antibacterial activities of Artocarpus lanceifolius Roxb bark. In Journal of Physics: Conference Series (Vol. 1341, No. 7, p. 072014). IOP Publishing.
Sophonnithiprasert T, Mahabusarakam W, Watanapokasin R. 2019. Artonin E menyadarkan apoptosis yang diinduksi TRAIL dengan peningkatan regulasi DR5 dan downregulasi cFLIP pada sel LoVo kanker kolorektal tahan api TRAIL. J Saluran Pencernaan Oncol 10 : 209-217
Syah, Y. M., Achmad, S. A., Ghisalberti, E. L., Hakim, E. H., Makmur, L., & Mujahidin, D. (2001). Artoindonesianins GI, three new isoprenylated flavones from Artocarpus lanceifolius. Fitoterapia, 72(7), 765-773.
Taleghani, A., & Tayarani-Najaran, Z. (2018). Potent cytotoxic natural flavonoids: The limits of perspective. Current pharmaceutical design, 24(46), 5555-5579.
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